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Revista de la Facultad de Medicina

Print version ISSN 0120-0011

Abstract

SALGADO, Doris Martha et al. Multi-organic dysfunction syndrome caused by dengue 3 in children of Neiva Huila, Colombia . rev.fac.med. [online]. 2008, vol.56, n.2, pp.147-155. ISSN 0120-0011.

Background. Dengue is the main arthropod -transmitted viral disease in the world with a growing number of cases in Neiva, Colombia. Clinical presentation of dengue hemorrhagic fever (DHF) is showing compromise of organs different from endothelium which could be associated to the circulating serotype and/or host immunological factors. Objetive. To alert about the association of multiple organic dysfunction (MOD) and DHF. Results. MOD associated to DHF is described in three girls with an average of 16 months of age, two 7-months-old and 1 three year old. The evolution of fever at the beginning was 4 days; they had shock resistant to usual treatment with crystalloids and colloids with tachycardia, ventricular arrhythmia, increased CPK MB, AST and ALT, coagulopathy with prolonged PTT and PT but without severe thrombocytopenia, metabolic alteration with acidemia and hypoglicemia in the three girls. Score for MOD was applied with an average of 23 and evidence of myocardial, hepatic and hematological major compromise. dengue 3 was showed by RT-PCR. Discussion. Similar reports are compared with these cases and probable physiopathological mechanisms are discussed. Conclusion. It has to be stressed that DHF might affect different organs, because of this definition of severity in dengue has to be reconsidered. An early thinking in different organs affected might help to introduce an opportune intervention or treatment.

Keywords : dengue hemorrhagic fever; dengue virus; insect vectors.

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