Abstract

LOPEZ G, Jorge J  and  VACCA, Claudia P. Use of immunosuppressive drugs in patients with kidney, liver or bone marrow transplant in a high complexity clinic in Bogotá, Colombia. rev.fac.med. [online]. 2009, vol.57, n.3, pp.227-235. ISSN 0120-0011.

Background. Organ transplantation is currently a therapeutic option for patients at the terminal stages of diverse pathologies. The use of immunosuppressants greatly contributes to the efficacy of these treatments by preventing organ rejection. The lack of follow-up to the use of new medications, like relatively expensive new immunosuppressants; plus the unjustified proliferation of new indications, may increase the costs of health care and generate risks for the patient. Objectives.To describe and characterize the use of immunosuppressant medications in recipients of renal, allogenic bone marrow and hepatic transplants. Methods. Cross-sectional study with retrospective collection of information spanning one year. This is a study of prescription habits. Results. The global outcome of transplantation therapy was satisfactory in 92,5 percent of the cases. Five point seven percent of the studied patients presented rejection with withdrawal of the graft, while only one patient died after having received the transplant. The most prescribed agent was mycophenolate mofetil with 41 prescriptions (28%), while the most consumed was prednisone with 2.38 daily defined doses/100 patients/day. Conclusions. Mycophenolate, cyclosporine and corticoids were present in most schemes, and there were a few prescriptions of monoclonal antibodies and antithymocitic therapy

Keywords : drug utilization studies; immunosuppressive drugs; transplants.

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