Abstract

ECHEVERRI-RUIZ, Nancy Paola  and  MOCKUS-SIVICKAS, Ismena. Cellular mechanisms in response to stress: sirtuin. rev.fac.med. [online]. 2010, vol.58, n.3, pp.221-232. ISSN 0120-0011.

The role of caloric restriction on longevity and prevention of chronic diseases has been known for some time; recently, cellular mechanisms involved are beginning to be elucidated. Cellular stress could be defined as the state in which the cell does not present optimal survival conditions; oxidative stress is a type of stress in which free radicals harmful cell structures. Caloric restriction might increase cellular resistance to various forms of stress. Sirtuins, histone deacetylases type III proteins are involved in the relationship between energy balance and gene transcription, allowing cell to respond to caloric restriction and to survive to oxidative stress. In this relationship, sirtuins regulate FOXO family genes, cMYC, hTERT, p53, among others. Activation or silencing of those genes is important in the process of apoptosis, repair and cell death

Keywords : energy supply; caloric restriction; aging; longevity; sirtuins; telomere; telomerase.

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