Resumo

RUIZ-MEJIA, Alba Fernanda  e  MOCKUS-SIVICKAS, Ismena. Current concepts regarding mechanisms regulating puberty. rev.fac.med. [online]. 2012, vol.60, n.1, pp.50-59. ISSN 0120-0011.

The onset of puberty depends on activating the hypothalamic-pituitary-gonadal axis. A glial and neuronal network interacts by means of adhesion molecules, growth factors, amino acids, peptides and lipid derivates, leading to information about an individual's metabolic state becoming integrated with that from the environment in the hypothalamus and thereby determining the start of the reproductive stage and its maintenance. Understanding about the factors intervening in puberty has become greater during the last few years, even though all the participating mechanisms have not yet been elucidated. This article reviews some of the most important cellular and molecular processes in regulating pulsatile gonadotropin-releasing hormone (GnRH) secretion, placing greater emphasis on the most recent knowledge.

Palavras-chave : puberty; metablic phenomena; hypothalamus; recptors; LHRH (MeSH).

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