Abstract

BEJARANO-RONCANCIO, Jhon Jairo; ALMARZA-LABARCA, Johan Carlos  and  VELOZA-NARANJOS, Angélica Lucía. Insulin analogues: clinical relevance and future perspectives. rev.fac.med. [online]. 2012, vol.60, n.4, pp.333-341. ISSN 0120-0011.

Insulin analogues have been engineered through recombinant DNA techniques for managing diabetic patients since the 1990s; modifications to the original human insulin molecule have made them rapid, ultrarapid and prolonged acting. Aspart, lispro and glulisine are ultrafast insulins and glargine and detemir are longacting ones. Such insulins may be premixed in formulations combining neutral protamine Hagedorn (NPH) with regular human insulin (70%/30%). Different types of therapeutic algorithms are available nowadays but insulinisation remains a crafted therapy based on the treating specialist's experience. The introduction of insulin analogues enables using correction boluses or extra doses of insulin to reduce hypoglycaemia at any time of the day and facilitates handling carbohydrates in a particular patient's diet.

Keywords : insulin,pharmacokinetics; diabetes mellitus; hypoglycemic; insulinsecreting cells.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )