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Revista de la Facultad de Medicina

Print version ISSN 0120-0011

Abstract

GRANADA, Juliana  and  RODRIGUEZ, Diego Andrés. Sodium fluoroacetate intoxication: case report. rev.fac.med. [online]. 2014, vol.62, n.1, pp.137-140. ISSN 0120-0011.  http://dx.doi.org/10.15446/revfacmed.v62n1.43781.

Sodium fluoroacetate is known as compound 1080; it was discovered by the German chemicals during World War II. It is a compound soluble in water, odorless and tasteless. The lethal dose 50 in humans is 2 to 4 mg/kg. Because of its lethality, it has been recalled in several countries including Colombia. This compound causes biochemical and physiological effects as citrate accumulation, altered mitochondrial Citrate transporter, the accumulation of lactic acid, impaired glucose regulation and hidroelectrolyte disorders (mainly calcium disturbances). The clinical manifestations of poisoning by this substance are non-specific, which males their identificacion and treatment difficult, making it to increase its lethality. Ethanol increases the level of acetat, thus providing an alternative substrate Krebs cycle and may offer benefits in the acute treatment of these patients; however, management support is the mainstay of management of these cases. Here it is reported a case of intentional ingestion in an adolescent, with delayed diagnosis a successful outcome.

Keywords : Flourine Compounds; Fluoride Poisoning; Poison, Poisoning; Toxicological Symptoms; Toxic Substances; Toxicity; Colombia; Child.

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