Abstract

PAZMINO, Freddy Alexander  and  NAVARRETE-JIMENEZ, Myriam Lucia. Immunologic mechanisms involved in the pathology of allergic asthma. rev.fac.med. [online]. 2014, vol.62, n.2, pp.265-277. ISSN 0120-0011.  https://doi.org/10.15446/revfacmed.v62n2.45417.

Asthma is a disease that affects people of different ages. The WHO estimates that it actually affects around 235 million people around the world, while in Colombia it estimates that is present in about 12% of the population. Asthma is characterized by an airway inflammation and a change in the structural tissue of the respiratory system as: caliciform cells epithelial hyperplasia, subepithelial collagen deposits and airway smooth muscular hypertrophy. Immunopathology of allergic asthma involves humoral and cell mediated immune response, altogether induces a state of airway hyperresponsiveness (AHR). Inflammatory cells involved in atopic asthma are: airway epithelial cells, different sub-populations of T y B cells, mast cells, dendritic cells, eosinophils, basophils, macrophages, iNKT cells and platelets, as well as cytokines, chemokines and costimulating and regulating signals. The present paper analyses some cellular and molecular processes, considered as the most important related to the immunopathology of atopic asthma.

Keywords : Asthma; Immunoglobulin E; Mast Cells; Eosinophils.

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