Abstract

ANCIZAR-ARISTIZABAL, Fabio; CASTIBLANCO-RODRIGUEZ, Ana Lucia; MARQUEZ, Diana Cecilia  and  RODRIGUEZ, Alba Isabel. Approaches and perspectives to toxicogenetics and toxicogenomics. rev.fac.med. [online]. 2014, vol.62, n.4, pp.605-615. ISSN 0120-0011.  https://doi.org/10.15446/revfacmed.v62n4.45218.

Toxicology is one of the scientific disciplines that has most evolved in recent years due to scientific and technological advances that have created a deeper understanding of the genetic and molecular basis for appreciative variability in toxic response from one person to another. The application of this knowledge in toxicology is known as toxicogenetics and toxicogenomics. The latter is the discipline that studies the genomic response of organisms exposed to chemical agents, including drugs, environmental pollutants, food additives, and other commonly used chemical products. The use of emerging omic technologies, such as genomics, transcriptomics, proteomics, metabolomics and bioinformatics techniques, permits the analysis of many variants of genes simultaneously in an organism exposed to toxic agents in order to search for genes susceptible to damage, to detect patterns and mechanisms of toxicity, and determine specific profiles of gene expression that give origin to biomarkers of exposure and risk. This constitutes predictive toxicology.

Keywords : Toxicogenetics; Toxicology; Genome.

        · abstract in Spanish     · text in English     · English ( pdf )