Abstract

RUIZ-FERNANDEZ, Nelina et al. Hypertriglyceridemic waist and cardiometabolic risk profile among normal weight and overweight adolescents. rev.fac.med. [online]. 2015, vol.63, n.2, pp.181-191. ISSN 0120-0011.  https://doi.org/10.15446/revfacmed.v63n2.49185.

Background. Hypertriglyceridemic waist phenotype (HW) is associated with high cardiometabolic risk (CMR) in adults; however, there is little information on whether it causes adverse metabolic changes in adolescents with and without excess body weight or not. Objective. To evaluate the profile of CMR associated with HW and its ability to predict CMR factors in adolescents, categorized by body mass index Z-score. Materials and methods. 96 adolescents (aged 12-17) divided into two groups (normal weight and overweight/obesity) were evaluated. Weight, height, waist circumference, blood pressure and biochemical markers of CMR were measured; the stage of sexual maturation was established. Clustered CMR index was calculated. Results. The frequency of HW was 9.8%. The number of cases of HW was higher in the later stages of sexual maturation (p<0.001) and in the overweight/obesity group (p=0.043). In the total group, the HW was able to predict the presence of high blood pressure (p<0.002), high cholesterol non-HDL (p<0.012) and elevated clustered CMR (p<0.001). In the normal weight group, the presence of HW significantly raised the triglycerides/ HDL-cholesterol ratio (p=0.003) and clustered CMR index (p=0.001); in the overweight/obesity group, HW increased systolic (p=0.005) and diastolic (p=0.006) blood pressure, total (p=0.037) and non-HDL (p=0.029) cholesterol, total cholesterol/ HDL-cholesterol ratio (p=0.032), triglycerides/HDL-cholesterol ratio (p<0.001) and the clustered CMR index (p<0.001), regardless of gender, age and stage of sexual maturation. Conclusions. HW was prevalent and associated with an adverse metabolic profile and high clustered CMR in adolescents with and without excess body weight, so its detection is recommended in primary care.

Keywords : Hypertriglyceridemic waist; Metabolism; Cardiovascular diseases; Adolescent.

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