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Revista de la Facultad de Medicina

Print version ISSN 0120-0011

Abstract

ANDRADE-CERQUERA, Ernesto  and  DIAZ-ROJAS, Jorge Augusto. Systematic review of studies on cost-effectiveness of cystic fibrosis carrier testing. rev.fac.med. [online]. 2016, vol.64, n.4, pp.671-677. ISSN 0120-0011.  http://dx.doi.org/10.15446/revfacmed.v64n4.54489.

Introduction:

Cystic fibrosis is considered the most common autosomal disease with multisystem complications in non-Hispanic white population.

Objective:

To review the available evidence on cost-effectiveness of the cystic fibrosis carrier testing compared to no intervention.

Materials and methods:

The databases of MEDLINE, Embase, NHS, EBM Reviews - Cochrane Database of Systematic Reviews, LILACS, Health Technology Assessment, Genetests.org, Genetsickkids.org and Web of Science were used to conduct a systematic review of the cost-effectiveness of performing the genetic test in cystic fibrosis patients. Cost-effectiveness studies were included without language or date of publication restrictions.

Results:

Only 13 studies were relevant for full review. Prenatal, preconception and mixed screening strategies were found. Health perspective was the most used; the discount rate applied was heterogeneous between 3.5% and 5%; the main analysis unit was the cost per detected carrier couple, followed by cost per averted birth with cystic fibrosis. It was evident that the most cost- effective strategy was preconception screening associated with prenatal test.

Conclusions:

A marked heterogeneity in the methodology was found, which led to incomparable results and to conclude that there are different approaches to this genetic test.

Keywords : Cystic Fibrosis; Review; Cost-Effectiveness Evaluation (MeSH)..

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