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Revista de la Facultad de Medicina

Print version ISSN 0120-0011

Abstract

BURGOS, Mariana  and  CABRERA, Rodrigo. Influence of HIF-1α rs11549465 polymorphism on hemoglobin and lactate levels in cardiovascular surgery patients. rev.fac.med. [online]. 2017, vol.65, n.2, pp.253-260. ISSN 0120-0011.  http://dx.doi.org/10.15446/revfacmed.v65n2.57337.

Introduction:

Perioperative anemia is a common complication of cardiovascular surgery. Patients who present the T allele of the HIF-1α rs11549465 polymorphism may have altered hemoglobin and lactate levels before, during and after surgery, compared to the wild-type allele, due to an increased stability of HIF-1α caused by this allele.

Objective:

To describe the frequency of the T allele in patients scheduled for cardiovascular surgery, and its relationship with hemoglobin and lactate levels.

Materials and methods:

DNA was isolated from 84 cardiovascular surgery patients for genotyping by Sanger sequencing. Demographic and clinical characteristics were collected.

Results:

The frequency of the T allele was 0.066 (95%CI: 0.0370.114). No significant differences were observed in preoperative, intraoperative, and postoperative hemoglobin and lactate levels between patients with the T allele and those with the wild-type allele.

Conclusion:

The frequency of the T allele is lower than expected according to other studies in healthy volunteers. No significant differences were observed in some Asian populations, nor in a group of acute myocardial infarction patients. Apparently, rs11549465 genotyping in cardiovascular surgery patients is not a valid risk stratification method for anemia in this group.

Keywords : Single Nucleotide Polymorphism; Cardiovascular Surgical Procedures; Lactic Acid (MeSH).

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