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Revista de la Facultad de Medicina

Print version ISSN 0120-0011

Abstract

ESPINOSA-ALMANZA, Carmelo José  and  GAITAN-DUARTE, Hernando. Chronic kidney disease and bleeding in patients under low molecular weight heparin prophylaxis. rev.fac.med. [online]. 2017, vol.65, n.4, pp.627-631. ISSN 0120-0011.  https://doi.org/10.15446/revfacmed.v65n4.59769.

Introduction:

The safety of low molecular weight heparin (LMWH) prophylaxis in patients with impaired kidney function remains undefined.

Objective:

To establish if the reduction of the glomerular filtration rate (GFR) is associated with the development of bleeding under LMWH prophylaxis.

Materials and methods:

A cohort of non-surgical patients with LMWH prophylaxis was constructed in order to conduct a case-control study. Monitoring allowed to find bleeding cases, while four controls were chosen from the population at risk at the time of bleeding onset.

Results:

Out of 716 monitored patients, 51 presented with bleeding, with an incidence of 3 cases per 100 patients per day of treatment; 39% of the cases presented with major bleeding and 204 controls were chosen. The multivariate analysis showed no relationship between bleeding and abnormal renal function due to GFR reduction. However, only 3.5% ofpatients had GFR <30ml/min. The final adjusted odds ratio (OR) was 1.27 and the 95% confidence interval (CI) was 0.60-2.68.

Conclusion:

No correlation was found between the reduction of mild to moderate GFR and the development of bleeding under LMWH prophylaxis.

Keywords : Deep Venous Thrombosis; Enoxaparin; Pulmonary Embolism (MeSH).

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