Abstract

GARCIA, Hugo et al. Residues of enrofloxacin and ciprofloxacin in muscle of broiler chickens. Rev Colom Cienc Pecua [online]. 2006, vol.19, n.1, pp.61-65. ISSN 0120-0690.

Fluoroquinolones are antimicrobials of intensive usage in veterinary medicine. In our country enrofloxacin is employed in poultry and pig production. Ciprofloxacin, the mayor metabolite of enrofloxacin, is a useful resource in human medicine and one alternative for farm animals. Both antimicrobials were simultaneously detected in muscle of chickens naturally infected with Mycoplasma synoviae and administrated with enrofloxacin or ciprofloxacin (5mg/kg/12h oral) for 5 days. The purpose of this work was to determine the adequate slaughter moment of the animals, with good clinical conditions and acceptable residue levels. The animals were sacrificed at 5 times after treatment. The samples (200 mg) were homogenized in phosphate buffer, and extracted twice with dichloromethane. The fluoroquinolones were detected by high performance liquid chromatography with fluorescence detection at 295 nm excitation and 500 nm emission. The concentration of enrofloxacin residues was maximal at 24 h after treatment (0.073 + 0.006 ìg/ g) and was lower than the maximal limit levels established by international regulations (0.3 ìg/g). In ciprofloxacin administrated animals the superior concentration of the antimicrobial in muscle was 72 h after treatment with 0.027 + 0.015 ìg/g. The consumers and the authorities must be concern about the control of veterinary residues in different products and edible tissues of farm animals.

Keywords : micoplasmosis; residuos; fluoroquinolonas; HPLC.

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