Abstract

GARCIA OVANDO, Hugo; PRIETO, Guillermo F; LUDERS, Carlos F  and  ERRECALDE, Carlos A. Plasma pharmacokinetic of balofloxacin in calves. Rev Colom Cienc Pecua [online]. 2008, vol.21, n.2, pp.259-264. ISSN 0120-0690.

Pharmacokinetic parameters of absorption and disposition of balofloxacin were determined in female Holando-Argentinean calves (n = 6), after a 5 mg/kg single dose, administered as both intravenous and subcutaneous bolus, in a crossed-over design treatment. The analyte was determined in plasma samples by microbiological method in agar diffusion, using a Bacillus subtilis BGA spore solution as microorganism detector in agar Antibiotic Nº 1. The plasmatic concentrations of balofloxacin based on the time were analyzed by a non compartimental kinetic model using software PK Solution 2.0. The intravenous pharmacokinetic parameters obtained were: t_1/2β= 2.3 ± 1.1 h; Cl_{total area}= 10.2 ± 3.4 ml/min/kg; Vd_área= 1.8 ± 0.3 L/kg; and AUC_área= 551.3 ± 247.0 µg/min/ml. Except for Cl_{total area} and AUC_area, the values obtained for the intravenous administration significantly differed from the obtained ones for the subcutaneous route (p<0.05), for which C_max= 1.3 ± 0.4 µg/ml, t_max= 51 ± 12.1 minutes and bioavailability values close to 98% were obtained. The Vd_area value was superior to 1 l/kg for both routes of application and indicates good capacity to spread to extravascular area and tissues.

Keywords : balofloxacin pharmacokinetic; Bos taurus; pharmacokinetic in calves.

        · abstract in Spanish | Portuguese     · text in Spanish     · Spanish ( pdf )