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Revista Colombiana de Ciencias Pecuarias

Print version ISSN 0120-0690
On-line version ISSN 2256-2958


ALVAREZ, Iván  and  FLOREZ, Yenny. Pathophysiological effects of rennin-angiotensin-aldosterone system on congestive heart failure in dogs. Rev Colom Cienc Pecua [online]. 2012, vol.25, n.3, pp.511-522. ISSN 0120-0690.

Heart failure is the second pathology of importance in long-lived dogs. It has been suggested that heart failure can be considered as a neurohormonal or neuroendocrine model, in which heart failure progresses as a result of over-expression of biologically active molecules that are able to exert a deleterious effect on the heart and circulation. Among these molecules is the rennin angiotensin aldosterone and its main effector peptide: the angiotensin II. In recent years, the pathophysiological consequences of the system have been the main focus of attention, being more relevant the alternative routes of angiotensin II synthesis and the participation of other enzymes such as the angiotensin converting enzyme. Therefore, this review aimed to describe the pathophysiological importance of the renin angiotensin aldosterone on Congestive Heart Failure.

Keywords : angiotensin II; angiotensin-converting enzyme; congestive heart failure; rennin angiotensin aldosteron system.

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