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Revista Colombiana de Ciencias Pecuarias

Print version ISSN 0120-0690


RUIZ, Jhon D; RAMIREZ, Juan E  and  LEZCANO, Ángel. Effects of two intravenouse dose levels of omeprazole on the gastric juice pH of healthy horses. Rev Colom Cienc Pecua [online]. 2016, vol.29, n.4, pp.283-287. ISSN 0120-0690.


omeprazole suppresses gastric acid secretion and increases gastric juice pH by blocking the H+, K+ ATPase in the secretory membrane of parietal cells. Gastric juice pH below 4, long periods of no feed intake and stress are factors predisposing to gastric ulcers in horses.


to determine the effect of 1 and 2 mg/Kg intravenous (IV) omeprazole on the gastric juice pH of Colombian Creole horses.


seven horses were treated with two IV levels of omeprazole (1, and 2 mg/Kg body weight (BW)) in a crossover design. The omeprazole dose for each animal was reconstituted with 100 ml 0.9% NaCl. Gastric pH was measured using a portable pH-meter in stomach samples collected at time 0 (just before treatment), and 1, 2, 3, 5, 7, 9, 11, and 24 hours post-treatment.


the gastric pH at time 0 fluctuated from 1.6 to 3.2 in all horses. Both omeprazole doses (1 and 2 mg/Kg) significantly increased the gastric pH (pH>4.6) from 1 to 11 hours after the treatment. At 24 hours post-treatment, pH of the group treated with 1.0 mg/Kg significantly decreased to 2.8 ± 0.3, but remained elevated at 5.7 ± 0.87 for the group treated with 2 mg/Kg.


the study demonstrated that a single IV omeprazole dose of 2 mg/Kg, but not 1 mg/Kg, maintained gastric pH above 4 during 24 hours.

Keywords : equine; stomach; ulcer.

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