SciELO - Scientific Electronic Library Online

 
vol.34 issue4Myelophthisis: Old aspects, new conceptsDoege-Potter syndrome: An inoperable fibrous tumor of the pleura associated with hypoglycemia author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Acta Medica Colombiana

Print version ISSN 0120-2448

Abstract

RESTREPO VALENCIA, César Augusto  and  MANJARRES IGLESIAS, Gilberto. Controversy about the use of bisphosphonates in patients with kidney disease. Acta Med Colomb [online]. 2009, vol.34, n.4, pp.176-184. ISSN 0120-2448.

Bisphosphonates are antiresorptive agents, thanks to their ability to alter the function of osteoclasts. They can even induce apoptosis of these cells. Other therapeutic benefits of these drugs are their anti-inflammatory action and their ability to inhibit the formation of atherosclerotic plaque. Classically, impaired renal function has been a contraindication to their use, but recent evidence has shown that proper dose adjustment, or selection of bisphosphonates with low toxicity and high fixation to serum protein and bone, as well as high clearance rates in dialysis therapy, could be an excellent therapeutic weapon in diseases that affect the kidneys and other organs, such as multiple myeloma, and in states of hyperphosphatemia associated with high bone turnover.

Keywords : bisphosphonates; kidneys disease; osteoclasts; atherosclerosis.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License