SciELO - Scientific Electronic Library Online

vol.35 número3Comparison of the pulmonary function of patients with type 2 diabetes mellitus treated with insulin injections versus that of patients treated with oral hypoglucemic agentsRestrictive cardiomyopathy as a presentation of amyloidosis índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados




Links relacionados

  • Em processo de indexaçãoCitado por Google
  • Não possue artigos similaresSimilares em SciELO
  • Em processo de indexaçãoSimilares em Google


Acta Medica Colombiana

versão impressa ISSN 0120-2448


ORTIZ, Johanna; NEWMAN, Steven Anthony; AREVALO, Sinay  e  RESTREPO, Héctor Fabio. Utility of (99m) Tc TRODAT-1 imaging in diagnosing Parkinson's disease. Acta Med Colomb [online]. 2010, vol.35, n.3, pp.119-125. ISSN 0120-2448.

Purpose: Parkinson disease (PD) is a degenerative disorder. The clinical symptoms of this disease are resting tremor, rigidity and bradykinesia. The purpose of this literature review is to determine the utility of TRODAT -1 in the diagnosis of PD. A search covered PUBMED, COCHRANE, MEDLINE, LILACS and SCIELO databases, between January 1998 and January 2008. Study selection: twenty six articles were obtained with their respective abstracts. After the first review, ten of them were chosen and only six of them met the inclusion criteria. Four articles were classified as grade evidence (+) and two as grade evidence (-) according to NICE guides. All the articles reviewed report significantly decreased striatal uptake of TRODAT-1 in early PD patients, suggesting that this is a useful, safe, and inexpensive tool in the diagnosis of early PD. It was not possible to perform a meta-analysis with the chosen articles because only three of them reported sensitivity and specificity, and each of these used different criteria for their semi-quantitative analyses. This variability makes comparison of the semiquantitative uptake criteria impossible. Conclusions: establishment of a universal technique for quantitation of TRODAT-1 uptake is necessary in order to make meta-analysis viable and allow comparison of the usefulness of this agent among large numbers of patients and multiple populations (Acta Med Colomb 2010; 35: 119-125).

Palavras-chave : Parkinson disease; parakysis agitans; Lewy bodies parkinson disease; 99m Tc TRODAT-1; SPECT, Single-Photon Emission-Computed Tomography; Radionuclide Tomography; Single-Photon Emission-Computed.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )


Creative Commons License Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons