Acta Medica Colombiana
versão impressa ISSN 0120-2448
VELASQUEZ, Carlos Jaime et al. Response to intravenous gammaglobulin in refractory Takayasu arteritis. Acta Med Colomb [online]. 2010, vol.35, n.3, pp. 139-142. ISSN 0120-2448.
Takayasu arteritis (TA) is a large-vessel vasculitis which affects the aorta and its major branches. Steroids are the cornerstone of treatment; however, more than half of the patients relapse, requiring additional immunosuppressive agents. Open studies have suggested that methotrexate, cyclophosphamide, azathioprine, mycophenolate mofetil and anti-TNF therapy may be useful in such cases. We conducted a case report of a patient with TA with multiple relapses despite methotrexate, steroids, rituximab, cyclophosphamide, infliximab, percutaneous, and surgical revascularization. Intravenous immunoglobulin (IVIg) was employed, obtaining total and sustained control of vasculitic manifestations, achieving tapering and suspension of steroids as well as diminution of acute phase reactants (Acta Med Colomb 2010; 35: 139-142).
Palavras-chave : Takayasu arteritis; immunoglobulins; intravenous.