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Acta Medica Colombiana

Print version ISSN 0120-2448


CANTILLO, Jorge de Jesús; FLOREZ, Adriana Alejandra; LOPEZ, Rocío del Pilar  and  ANDRADE, Rafael Enrique. Monoclonal gammopathy of undetermined significance Apropos of a case of lambda light chain deposition nephropathy. Acta Med Colomb [online]. 2014, vol.39, n.2, pp.196-201. ISSN 0120-2448.

Nephropathy associated with monoclonal gammopathies is mainly due to light chain deposition. The paraproteinemic kidney diseases are lesions associated with deposition of intact immunoglobulins or fragments of immunoglobulins (heavy and light chains). The disease due to deposition of light chains is a rare condition characterized by deposition of monoclonal light chains in many organs and as for the kidney, predominantly in glomeruli and tubular basement membranes. The disease is frequently associated with lymphoproliferative disorders and the majority of cases are caused by deposition of kappa light chains. Although presented primarily in clinical pictures of malignancy, sometimes no hematological pathology is detected and is called idiopathic or "primary". It usually manifests as severe renal failure with nephrotic proteinuria, has not a clearly established treatment and the prognosis is poor. The clinical and histological features of the second case reported in Colombia of a light chain deposition nephropathy diagnosed in the context of a kidney paraproteinemic disease without malignancy data, is presented. (Acta Med Colomb 2014; 39: 196-201).

Keywords : monoclonal immunoglobulin deposition disease; light chain deposition disease; nephropathy; paraproteinaemic kidney disease; monoclonal gammopathy; plasma cell dyscrasia.

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