Abstract

ROJAS, William; LANCHEROS, Andrés  and  TAPIERO, Mireya. Description of cardiac disorders by echocardiography in patients with acromegaly. Acta Med Colomb [online]. 2015, vol.40, n.1, pp.30-35. ISSN 0120-2448.

Objective: to describe echocardiographic abnormalities in patients with acromegaly in the Hospital San José, Endocrinology Service. Methodology: case series of patients who attended the service acromegaly clinic. A description of the clinical features related to the underlying disease and its comorbidities was made. Cardiac involvement was documented by electrocardiogram, evaluating arrhythmias and prolonged QT. The study by transthoracic echocardiography identified left ventricular ejection fraction, valve dysfunction, pulmonary hypertension and ventricular segmental motility disorder. Results: data of 26 patients was obtained. 69% female, 61% over 50 years, with a median disease progression of five years. 92% showed macroadenoma and most of them underwent surgery. In 21 echocardiographic reports 61% of patients had LVEF greater than 60% and none had LVEF less than 45%; 38% of patients had left ventricular hypertrophy. Diastolic dysfunction was reported in 21%, mild mitral insufficiency in 14%, mild aortic stenosis in 4%. 24 electrocardiograms were performed, all with evidence of sinus rhythm, premature ventricular contractions in 12.5% without QT prolongation. Conclusion: no compromise on ejection fraction or motility disorders were detected and there was a low frequency of diastolic dysfunction; ventricular hypertrophy and valvular abnormalities were less frequent than that reported in the literature and ventricular premature beats as a single electrocardiographic abnormality were documented. (Acta Med Colomb 2015; 40: 30-35).

Keywords : acromegaly; growth hormone; cardiovascular disease; acromegalic heart disease; echocardiography.

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