Introduction:

chronic kidney disease is associated with severe metabolic abnormalities that lead to secondary hyperparathyroidism (SHPT). Kidney transplant corrects pathophysiological abnormalities that originate it.

Objective:

to describe changes at one year and at three years of follow- up of serum levels of intact parathyroid hormone (PTH) and calcium-phosphorus profile in patients undergoing renal transplantation with a previous diagnosis of SHPT.

Methodology:

a descriptive analysis of all patients transplanted between 2005 and 2012 was performed assessing levels of iPTH and calcium-phosphorus profile before transplantation, and after one year and three years of follow-up.

Results:

pre-transplant iPTH average of 175 patients was 465.4 pg / dL; in 30.2% of patients levels higher to nine times the normal value were found. At one year follow-up, glomerular filtration rate (GFR) average was 65.4 mL / min / 1.73 rtf. PTH (114 patients), averaged 118.7 pg / dL, with an average decrease of 339 pg / dL. PTH was greater in those with GFR less than 40. In the third year of follow-up findings were maintained in all patients with iPTH average of 100.4 pg / dL (a decrease of 396 pg / dL).

Conclusions:

in this study it was found that SHPT improves after renal transplantation, with a significant reduction in iPTH levels to the first and third years of follow-up. (Acta Med Colomb 2016 41: 111-115).