SciELO - Scientific Electronic Library Online

vol.42 issue2Randomized and controlled clinical trial of the effect of cocoa consumption in patients with insulin resistanceObserved versus expected mortality in a network of dialysis units in Colombia author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand



Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Acta Medica Colombiana

Print version ISSN 0120-2448


LONDONO, Jessica María et al. Association of clinical variables of hypoperfusion with lactate and mortality. Acta Med Colomb [online]. 2017, vol.42, n.2, pp.97-105. ISSN 0120-2448.


among patients with infection, hyperlactatemia identifies a population of greater severity. This study aims to determine the correlation and association between clinical perfusion parameters and lactate values in emergency patients at the time of admission, as well as the change in clinical parameters with lactate clearance. In addition, to determine the association between these variables and in-hospital mortality.


Prospective cohort of patients admitted with suspected infection to a third level hospital. Lactate was measured at admission, at 6 and 24 hours, concomitantly with the variables capillary filling, shock index and pulse pressure, among others. Among the clinical variables, Spearman correlation, lactate levels and their clearance, as well as ROC curves to determine the discriminative ability of clinical variables to detect hyperlactatemia were performed. A multivariate logistic regression model for mortality was carried out.


2257 patients were evaluated. 651 were confirmed with infections. No utility correlation was found between clinical variables and lactate (r <0.25), and no discriminative capacity was detected for the detection of hyperlactatemia with any clinical variable (AUC <0.61). In the multivariate logistic regression model the lactate value at admission was the only variable that was independently associated with mortality (OR = 1.4, 95% CI = 1.3-1.6).


no correlation was found between clinical variables and lactate among patients admitted to the emergency department with infection; however lactate at admission is an independent prognostic marker of mortality. (Acta Med Colomb 2017: 42: 97-105).

Keywords : lactate; hypoperfusion; shock; sepsis; infection; early detection.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )