SciELO - Scientific Electronic Library Online

vol.42 issue2Nephrotic syndrome secondary to membranoproliferative glomerulonephritis due to Sjögren's syndrome author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand



Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Acta Medica Colombiana

Print version ISSN 0120-2448


MONTOYA, Mario; BARRANCO, Luis Alberto  and  HERRERA, Felipe. Acute porphyria. Diagnostic dilemma and neuroendocrine manifestations. Acta Med Colomb [online]. 2017, vol.42, n.2, pp.140-143. ISSN 0120-2448.

Acute intermittent porphyria (AIP) is an infrequent and considered orphan disease, characterized by neurovisceral crisis, being abdominal pain the most common symptom, accompanied in many cases by non-specific symptoms, making early diagnosis difficult. The delay in the diagnosis and treatment of this entity can be catastrophic or even fatal, causing long-term or permanent neurological damage. The case of a young adult who attends medical consultation several times for non-specific abdominal pain and 24 hours after admission develops sympathetic autonomic instability with elevated blood pressure and tachycardia is presented. He subsequently presents muscular weakness that evolves to quadriplegia and hyponatremia with criteria for inadequate secretion of antidiuretic hormone (SIADH). These data together with reddish urine staining lead to the diagnosis of porphyria. The clinical and biochemical characteristics emphasizing the importance of including porphyria within the differential diagnoses of abdominal pain and dysautonomia of indeterminate cause are presented. (Acta Med Colomb 2017; 42: 140-143).

Keywords : porphyrias; acute intermittent porphyria; quadriplegia; syndrome of inadequate ADH secretion; neuropathy; dysautonomia.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )