Objective:

to evaluate the association between cardio-metabolic or social risk factors with the progression to mild cognitive impairment (MCI) or dementia, in autonomous adults of Bogotá.

Material and methods:

a cohort of normal subjects with MCI, from the 2012-2014 study was re-evaluated applying the neuropsychiatric and neuropsychological protocol of the previous study. Multiple correspondence and logistic regression analyzes were performed.

Results:

215 autonomous adults were re-evaluated; 118 subjects had been diagnosed with normal cognition and 97 with MCI in the first study; 73% were women with an average age of 71 (SD: 7.3) years and schooling of 8.2 (SD: 5.4) years. 6% of the subjects progressed to dementia in a time of 4 (SD: 1) years. 75% of normal subjects remained unchanged and 22% progressed to MCI while 65% of subjects with MCI did not change and 25% normalized. Progressing from normal to MCI was associated with low schooling OR = 2.43 (95% CI 1.004-5.91; p = 0.049) and from MCI to dementia with BMI≤25 OR = 6.3 (IC95% 1.26-31; p = 0.025).

Conclusion:

having low schooling (≤5 years) was associated in normal subjects with a higher risk of progression to MCI, while having a BMI ≤25 increased the risk of progression to dementia in subjects with MCI. Protective factors in subjects who normalized were not identified. (Acta Med Colomb 2019; 44: 66-74).