Abstract

CONTRERAS-VILLAMIZAR, Kateir Mariel et al. Diffuse alveolar hemorrhage secondary to ANCA-associated vasculitis. Relapse during hemodialysis. Acta Med Colomb [online]. 2019, vol.44, n.2, pp.111-114. ISSN 0120-2448.

Massive diffuse alveolar hemorrhage (DAH) is an unusual complication of patients with ANCA vasculitis that frequently threatens life and is associated with mortality up to 100%. In formation in the literature about treatment in refractory cases and when the patient is on dialysis is scarce. The case of a patient with p-ANCA vasculitis with renal and pulmonary involvement in the lung-kidney syndrome scenario, with multiple relapses of alveolar hemorrhage despite treatment with corticosteroid, azathioprine, cyclophosphamide and plasma exchange therapy is presented. Management with anti-CD20 monoclonal antibody and immunoglobulin was estab lished, achieving resolution of the episode of alveolar hemorrhage and remaining without activity. The usefulness of rituximab as a therapeutic strategy in refractory cases is highlighted. (Acta Med Colomb 2019; 44: 111-114).

Keywords : hemodialysis; diffuse alveolar hemorrhage; plasma exchange; rituximab; vasculitis associated with antineutrophil cytoplasmic antibodies.

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