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Acta Medica Colombiana
versión impresa ISSN 0120-2448
Resumen
DOMINGUEZ-RAMIREZ, Gustavo Adolfo; BLANCO-PERTUZ, Paola María y HERRERA-RUEDA, Guillermo Andrés. Atypical hemolytic-uremic syndrome (aHUS). Acta Med Colomb [online]. 2019, vol.44, n.4, pp.42-44. ISSN 0120-2448. https://doi.org/10.36104/amc.2019.1301.
Atypical hemolytic-uremic syndrome (aHUS) is a diagnosis of exclusion which should be proposed in cases where there is microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury. It is associated with mutations which cause dysregulation of the complement system and implies an adverse prognosis and a high risk of progression to chronic kidney disease. Following, we present the case of a patient with aHUS, highlighting the effect and importance of biologic therapy with the monoclonal antibody eculizumab. (Acta Med Colomb 2019; 44. DOI:https://doi.org/10.36104/amc.2019.1301).
Palabras clave : atypical hemolytic-uremic syndrome; complement activation; thrombotic microangiopathies; chronic renal failure; monoclonal antibodies.