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Acta Medica Colombiana
Print version ISSN 0120-2448
Abstract
MELENDEZ-NEGRETTE, Fernando José; ESCUDERO-PINEDA, Pablo Andrés; DIAZ-PACHECO, Carlos Alberto and BUILES-BARRERA, Carlos Alfonso. Sampling of the petrosal sinuses. Indications, results and usefulness. Acta Med Colomb [online]. 2020, vol.45, n.4, pp.20-28. Epub June 09, 2021. ISSN 0120-2448. https://doi.org/10.36104/amc.2020.1479.
Objectives:
to analyze, evaluate and describe the usefulness of petrosal sinus sampling for diagnosing central Cushing's syndrome.
Materials and methods:
the technical aspects and results of bilateral venous sampling of the petrosal sinuses at the Hospital Universitario San Vicente de Paul in Medellín, Colombia, from January 1, 2012 to December 31, 2018, were analyzed.
Results:
the average age was 43.3 years, with a range from 19 to 69 years. Laterality could be shown in 68.2% of cases, with a tendency to be located on the left in 53.3%. The central source of ACTH production could be shown in 95.4% of cases, with a basal average central/peripheral ratio of 21.7, and 70.8 after stimulation. All samples at 3, 5 and 10 minutes were confirmatory following stimulation.
Conclusion:
in our retrospective study, petrosal sinus catheterization provided laboratory confirmation of the central source of ACTH production in a high percentage of patients, with no immediate complications.
Keywords : Cushing's syndrome; pituitary adrenocorticotropic hormone hypersecretion; petrosal sinus sampling; phlebography; pituitary diseases; ACTH-secreting pituitary adenoma.
