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Acta Medica Colombiana
Print version ISSN 0120-2448
Abstract
MUNOZ-LOMBO, JENNY PATRICIA et al. Multimorbidity and geriatric syndromes. Their effect on mortality in older adults with sepsis. Acta Med Colomb [online]. 2022, vol.47, n.1, pp.7-14. Epub May 06, 2022. ISSN 0120-2448. https://doi.org/10.36104/amc.2022.2125.
Introduction:
sepsis is diagnosed in more than 60% of older adults (OAs) worldwide. These OAs often have multimorbidity and one of the geriatric syndromes, leading to physical, cognitive and psychosocial disability with consequently high healthcare costs, resulting in a serious public health problem.
Objective:
to determine the impact of multimorbidity and geriatric syndromes on the 30-day mortality rate of OAs hospitalized for sepsis in an acute geriatric unit.
Materials and methods:
an observational, analytical, nested case-control study.
Results:
238 patients with a mean age of 83.15±7.12 were analyzed; 52.1% were women and 99% had at least one comorbidity; the 30-day mortality was 34%. Urinary tract infection was the main cause of hospitalization (42.9%), with microbiological isolation achieved in 43.3% of cases and Escherichia coli being the most common causal agent (46.6%). Multiple logistic regression showed that chronic kidney disease (OR 2.1 95% CI 1.1-4.8; p=0.037), delirium (OR 3.1 95% CI 1.6-5.8; p=0.001) and disability (Barthel index <60; OR 3.4 95% CI 1.5-7.5; p=0.002) were significantly related to 30-day mortality in patients with sepsis admitted to an acute geriatric unit.
Conclusion:
in OAs hospitalized for sepsis, multimorbidity, chronic kidney disease and geriatric syndromes (represented by delirium and disability) were the predictors of 30-day mortality. (Acta Med Colomb 2022; 47. DOI:https://doi.org/10.36104/amc.2022.2125).
Keywords : hospitalization; sepsis; geriatric syndrome; multimorbidity; comprehensive geriatric assessment; mortality.