Abstract

RAMIREZ, Alejandro; SIERRA, Ligia  and  LOPEZ, Betty Lucy. SYNTHESIS AND CHARACTERIZATION OF MESOPOROUS STATIONARY PHASES USING CHROMATOGRAPHIC TESTS AND QUANTITATIVE STRUCTURE-RETENTION RELATIONSHIPS. Rev.Colomb.Quim. [online]. 2006, vol.35, n.2, pp.147-162. ISSN 0120-2804.

In this work the synthesis, functionalization and chromatographic evaluation of three mesoporous silicas with different physical chemistry properties are described. The materials were prepared, as isomorphic micrometric particles, according to established methods and they were chemically modified by a classic procedure of silylation with octyldimethylchlorosilane followed by secondary silylation or end-capping. Galushko’ s test and quantitative structure-retention relationships were implemented for the chromatographic evaluation. A comparative study was done by comparing the parameters obtained with those reported in literature for five commercial columns. Although the chromatographic behavior is the expected for octyl phases, the new materials show larger hydrophobicity and chemical inactivity when compared with traditional columns. The asymmetric behavior of the peaks is attributed to packing irregularities due to a larger dispersion in particle size and morphology.

Keywords : Stationary phases; mesoporous silica; HPLC; quantitative structureretention relationships; hydrophobicity.

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