Abstract

PACHECO, Diana P et al. VALIDITY OF THE EXTENDED HILDEBRAND SOLUBILITY APPROACH IN THE ESTIMATION OF IBUPROFEN AND NAPROXEN SOLUBILITIES IN PROPYLENE GLYCOL + ETHANOL MIXTURES. Rev.Colomb.Quim. [online]. 2007, vol.36, n.1, pp.55-72. ISSN 0120-2804.

In this work the Extended Hildebrand Solubility Approach (EHSA) developed by Martin et al ., has been applied to evaluate the solubility of ibuprofen (IBP) and naproxen (NAP) in propylene glycol + ethanol cosolvent mixtures at 298.15 K ± 0.05 K. Apparent molar volumes of the solutes and the volumetric fraction of the solvents in the saturated solutions were employed. A good predictive capacity of EHSA was found using regular polynomial models of order four for IBP and of order three for NAP, when the W interaction parameter was related to the solubility parameter of the solvent mixtures. Nevertheless, the deviations obtained for the estimated solubility respect to experimental solubility were of the same order as compared with those obtained directly using empiric regressions of the experimental solubilities as a function of the cosolvent solubility parameters.

Keywords : Ibuprofen; Naproxen; Solubility estimation; Extended Hildebrand Solubility Approach; Cosolvent mixtures.

        · abstract in Spanish | Portuguese     · text in Spanish     · Spanish ( pdf )