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Revista Colombiana de Química
versão impressa ISSN 0120-2804versão On-line ISSN 2357-3791
Resumo
A, Erika; PLAZAS, G; CUCA S, Luis E e DELGADO A, Wilman A. FLAVONOIDS FROM INFLORESCENCES OF Piper hispidum Kunth (PIPERACEAE) AND ACETYLATED DERIVATIVES. Rev.Colomb.Quim. [online]. 2008, vol.37, n.2, pp.135-144. ISSN 0120-2804.
From the ethanolic extract of the inflorescences of Piper hispidum Kunth (Piperaceae) were isolated three flavonoids 5-hydroxy-7-methoxyflavanone, 5-hydroxy-4,7-dimethoxyflavanone and 2,4,6-trimethoxydihydrochalcone. The acetylated derivatives 5-acetoxy- 7-methoxyflavanone and 5-acetoxy- 4,7- dimethoxyflavanone were synthesized from the isolated pure flavanones. Characterization was mainly achieved by spectroscopic techniques and compared with literature data. Natural compounds and derivatives were subjected to brine shrimp lethality bioassay. The most toxic compound was the flavonoid 5-hydroxy- 7-methoxyflavanone with a LC50 1,8 [1]g/ml.
Palavras-chave : Piper hispidum Kunth; Piperaceae; flavanones; dihydrochalcones; acetylated derivatives and brine shrimp lethality assay.