Abstract

VILLAMIZAR, Laura F  and  MARTINEZ, Fleming. PHYSICOCHEMICAL STUDY OF THE SOLUBILITY OF EUDRAGIT S100® IN SOME AQUEOUS AND ORGANIC SYSTEMS. Rev.Colomb.Quim. [online]. 2008, vol.37, n.2, pp.173-187. ISSN 0120-2804.

In this paper the solubility of Eudragit S100® was studied with respect to pH in aqueous media and with respect to the polarity of some organic solvents. The polymer solubility parameter [1], was established by means of experimental solubility determinations and by theoretical ways, by using the Fedors and van Krevelen methods, which are based on groups’ contribution. The respective solubility map was thus established. The results show that the polymer is soluble in water over pH 6.0. The [1] value obtained experimentally was 12.9 [1] 2.4 cal1/2 cm-3/2, which is almost concordant with those obtained by means of Fedors and van Krevelen’s methods. In turn, the Teas diagram was developed for identifying the solvents and non-solvents for this polymer.

Keywords : Eudragit S100®; polymers’ solubility; solubility parameter; Fedors; van Krevelen methods.

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