Resumo

GUZMAN V, Juan D  e  CUCA S, Luis E. SECONDARY METABOLITES ISOLATED FROM THE BARK OF Dugandiodendron argyrotrichum Lozano (MAGNOLIACEAE). Rev.Colomb.Quim. [online]. 2008, vol.37, n.3, pp.275-286. ISSN 0120-2804.

From the ethanolic extract of the bark of the colombian endangered tree Dugan- diodendron argyrotrichum (Magnoliaceae) was isolated an oil in which major compounds were sesquiterpenes. Two sesquiterpenoids torreyol and parthenolide and the aporphine alkaloid N-acetylanonaine were isolated by column chromatography (CG-EM) and characterized by 1H and 13C nuclear magnetic resonance (NMR) spectroscopy. The isolated substances were subjected to brine shrimp lethality bioassay. The most toxic compounds were sesquiterpene oil (LC50 = 4,49 mg/ml) and dibenzylbutane lignans (1) (LC50 ~ 50 mg/ml).

Palavras-chave : sesquiterpenes; lignans; alkaloids; citotoxicity.

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