Abstract

RUIDIAZ, Miller A.  and  MARTINEZ, Fleming. EXTENDED HILDEBRAND SOLUBILITY APPROACH IN THE ESTIMATION OF INDOMETHACIN SOLUBILITY IN ETHYL ACETATE + ETHANOL MIXTURES. Rev.Colomb.Quim. [online]. 2009, vol.38, n.2, pp.235-247. ISSN 0120-2804.

Indomethacin (IMC) is a widely used as a non-steroidal anti-inflammatory drug, whose physicochemical properties have not been thoroughly studied. In this work the Extended Hildebrand Solubility Approach (EHSA) was applied to evaluate the solubility of IMC in ethyl acetate + ethanol mixtures at 298.15 K. A good predictive capacity of EHSA was found using regular polynomial models in order five, when the W interaction parameter is related to the solubility parameter of the mixtures. Nevertheless, the deviations obtained in the estimated solubility with respect to experimental solubility were oi the same order when compared with those obtained directly by means oian empiric regression oi the experimental solubility as a iunction oi the mixtures solubility parameters.

Keywords : indomethacin; solubility estimation; extended Hildebrand solubility approach; binary mixtures.

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