Abstract

MOYANO, Daniel F et al. EVALUATION OF THE CITOTOXICITY AND ANTIMICROBIAL ACTIVITY OF THE [Ag(phen)₂]salH COMPOUND. Rev.Colomb.Quim. [online]. 2012, vol.41, n.1, pp.47-59. ISSN 0120-2804.

This article evaluated the antimicrobial and cytotoxic activity of a new complex of silver(I) with the salicylate ion and 1,10-phenanthroline. The characterization of this compounds was performed by nuclear magnetic resonance spectroscopy of proton and carbon-13 (RMN ¹H y ¹³C), spectroscopy absorption in the infrared (IR), thermal analysis (TG/DCS) and elemental analysis (CHN). The results ob-tained through these methods suggest the formation of the compound with empiri-cal formula Ag(phen)₂]salH 4. When was compared the antimicrobial activity and cytotoxicity of the complex with other compounds of silver(I) and copper(II) of known activity, we observed that 1, 10-phenalthroline ligand increases these properties. The compound under study has the highest inhibition of bacterial growth, Gram-positive microorganisms were the most susceptible. The cytotoxic activity was tested against a panel of fve human cancer cell lines: MDA-MB231, PC-3, HT-29, HEp-2 and A549. At the concentrations tested, the compound pro-duced a dose-dependent cytotoxic res-ponse against all tumor cell lines, parti-cularly against the HT-29, MDA-MB231 and A549 cell lines. All this suggests its potential chemotherapeutic use.

Keywords : complexes of silver(I); 1,10-phenanthroline; antimicrobial ac-tivity; cytotoxic activity.

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