Abstract

AHUMADA, Edgar A; DELGADO, Daniel R  and  MARTINEZ, Fleming. Solubility of acetaminophen in polyethylene glycol400 + water mixtures according to the extended Hildebrand. Rev.Colomb.Quim. [online]. 2012, vol.41, n.3, pp.433-477. ISSN 0120-2804.

The Extended Hildebrand Solubility Approach(EHSA) was applied in the present work to evaluate the solubility of the analgesic drug acetaminophen (paracetamol) in polyethylene glycol 400 + water mixtures at 298.15 K. An acceptable correlative capacity of EHSA was found using a regular polynomial model in order four (overall deviation below 0.7%), when the W interaction parameter is related to the solubility parameter of the mixtures. Thus, the deviations obtained in the estimated solubility with respect to experimental solubility were lower than those obtained directly by means of an empiric regression of the experimental solubility as a function of the mixtures´ solubility parameters (close to 1.5%).

Keywords : acetaminophen; binary mixtures; extended Hildebrand solubility approach; solubility parameter.

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