Abstract

DELGADO, Daniel R. et al. Validation of an analytical method for the study of the solubility of some sulfonamides in cosolvent mixtures by ultraviolet spectrophotometry. Rev.Colomb.Quim. [online]. 2013, vol.42, n.3, pp.387-412. ISSN 0120-2804.

An analytical method by UV-spectrophotometry has been proposed and validated to study the solubility of some sulfonamides in cosolvent mixtures. The parameters evaluated were specificity, linearity, precision, and detection and quantification limits, as well as the drug stability under the solubility analysis conditions. The developed method was useful to determine the solubility of these drugs as a function of temperature and cosolvent concentration.

Keywords : Validation; UV/VIS-spectrophotometry; sulfonamides; solubility.

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