SciELO - Scientific Electronic Library Online

vol.45 issue1Nanocrystals for the degradation of a pollutant dye author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Revista Colombiana de Química

Print version ISSN 0120-2804


DELGADO, Daniel R; PENA, María Á  and  MARTINEZ, Fleming. Extended Hildebrand solubility approach applied to some structurally related sulfonamides in ethanol + water mixtures. Rev.Colomb.Quim. [online]. 2016, vol.45, n.1, pp.34-43. ISSN 0120-2804.

Extended Hildebrand Solubility Approach (EHSA) was applied to evaluate the solubility of sulfadiazine, sulfamerazine, and sulfamethazine in some ethanol + water mixtures at 298.15 K. Reported experimental equilibrium solubilities and some fusion properties of these drugs were used for the calculations. In particular, a good predictive character of EHSA (with mean deviations lower than 3.0%) were found by using regular polynomials in order four correlating the interaction parameter W with the Hildebrand solubility parameter of solvent mixtures without drug. The predictive character of EHSA was the same as that obtained by direct correlation of drug solubilities with the same descriptor of polarity of the cosolvent mixtures.

Keywords : Sulfonamides; ethanol; binary mixtures; extended Hildebrand solubility approach; Hildebrand solubility parameter.

        · abstract in Spanish | Portuguese     · text in English     · English ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License