Resumo

GORDILLO, Mónica A; ZULUAGA, Fabio  e  CHAUR, Manuel N. Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics. Rev.Colomb.Quim. [online]. 2016, vol.45, n.3, pp.39-50. ISSN 0120-2804.  https://doi.org/10.15446/rev.colomb.quim.v45n3.61408.

The kinetic and thermodynamic selectivity of acylhydrazone formation in dynamic combinatorial libraries (DCL) is described. Competition reactions were generated from hydrazides: isoniazid, 4-nitro-benzohydrazide, 4-dimethylamino-benzohydrazide, and nicotinic hydrazide as well as the aldehyde derivatives: benzaldehyde and 2-pyridine-carboxaldehyde. The obtained species and the distribution of the DCLs were monitored by 'H-NMR spectroscopy finding that those acylhydrazones containing the 4-dimethylamino-benzohydrazide moiety are both the kinetic and thermodynamic product of their respective libraries. Configurational and coordination dynamics for some of these libraries were also investigated. The obtained results allowed the study of the redistribution of components and the amplification of one or more products using light and metal ions as physical and chemical templates, respectively.

Palavras-chave : Dynamic combinatorial chemistry; acylhydrazones; coordination and configurational dynamics.

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