Abstract

CIRO, J; LOPEZ, A  and  PARRA, J. E. coli LIPOPOLYSACCHARIDES INCREASES THE PßD-2 MOLECULAR EXPRESSION IN JEJUNUM OF POSTWEANING PIGLETS. Rev. Med. Vet. Zoot. [online]. 2014, vol.61, n.2, pp.142-152. ISSN 0120-2952.  https://doi.org/10.15446/rfmvz.v61n2.44677.

Objective: To evaluate the effect on jejunum inflammation induced by consumption of E. coli LPS on PβD-2 molecular expression in weaned piglets. Materials and methods: The experiment was conducted in San Pablo Production Center of the Universidad Nacional de Colombia (Medellin). 32 weaned pigs at 21 days of age were used. Animals were fed for 10 days with a basal diet of milk and some of its derivatives, and that also fulfilled all and 10 days after weaning and a complete extraction of jejunum was realized. To induce intestinal inflammation animals were fed a basal diet supplemented with 0.3 µg de LPS/mg feed). A randomized block design in a 2x4 factorial arrangement was used. Results: There was increase (P<0.01) in PβD-2 molecular expression in animals fed the diet with higher levels of inclusion of LPS. Conclusions: LPS from E. coli increases expression of PβD-2 secreted to the intestinal defense, this leads to imbalance in cellular differenthe nutritionals minimums. Pigs were sequentially slaughtered on days one, five, seven, tiation in the intestine. This cellular imbalance may cause the presentation of intestinal morphological changes characterized by the decrease in villus height and increased crypt depth, reduction in enzyme activity and nutrient absorption, and eventually diarrhea.

Keywords : Weaning; diarrheas; fever; piglet.

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