Abstract

GALVIS, R. D.; MONTOYA, J. A.  and  MADRID, L. V.. Effect of the level of complementation with methionine-coline in Holstein cows during the transitional period on the hepatic concentrations of triglycerides, choline and carnitine. Rev. Med. Vet. Zoot. [online]. 2018, vol.65, n.3, pp.269-281. ISSN 0120-2952.  https://doi.org/10.15446/rfmvz.v65n3.76464.

In order to evaluate the lipotropic potential of methionine-coline in dairy cows during the transition period, the effect of supplementation with 20 g / d of a Ruminal Degradation Protected Commercial Source (FCPDR) of methionine was evaluated, and their combinations with a choline FCPDR in doses of 60 and 120 g / day. Cows grazed kikuyo (Cenchrus clandestinus) and received a nutritional supplement between day 260 of gestation and day 20 postpartum. On day 270 of gestation and on days 10 and 20 postpartum blood samples and liver biopsy were taken, in which were quantified: Non-esterified Fatty Acids (NEFAS), β-Hydroxybutyrate (BHB) and Triglycerides; And hepatic concentrations of triacylglycerides, choline, total carnitine, free carnitine and acyl carnitine. The highest values (p < 0.05) of plasma triglycerides and the significantly lower values (p < 0.05) of AGNES and BHB were presented during the prepartum. Hepatic concentrations of triglycerides, choline and different forms of carnitine did not differ significantly between sampling periods, and were unaffected by methionine-choline supplementation. Plasma concentrations of BHB increased significantly (p < 0.05) with co-supplementation with methionine and choline, suggesting an increase in fatty acid oxidation. At relatively low concentrations of AGNES, methionine and choline are not limiting nutrients for the exportation of triglycerides from the liver to the blood, therefore under this condition no hepatic lipidosis was observed and consequently methionine-choline supplementation did not cause significant effects on hepatic triglyceride concentrations.

Keywords : early lactation; hepatic lipidosis; lipotropic factors; metabolic diseases.

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