Abstract

CASTANEDA-DUQUE, J.  and  MOLINA, V. M.. Use of pralidoxime in methomyl intoxication in a Collie Shepherd in Medellín (Colombia). Case report. Rev. Med. Vet. Zoot. [online]. 2019, vol.66, n.2, pp.162-178. ISSN 0120-2952.  https://doi.org/10.15446/rfmvz.v66n2.82436.

The use of pralidoxime in the treatment of intoxication by methomyl in a canine of the city of Medellín (Colombia) is described. A male of the Collie Shepherd breed who accidentally intoxicated itself with methomyl and presented cholinergic profile with myosis, sialorrhea, delirium, excitement and emesis, was subjected to decontamination with activated charcoal and therapy with atropine (0.04 mg/kg IM) every 30 minutes until atropinization; diphenhydramine (2 mg/kg IV) every 8 hours, pralidoxime (10 mg/kg IV) every 8 hours; and pentobarbital (12 mg/kg IV) for 24 hours, in addition to supportive therapy. Hematological, creatinine, alanine aminotransferase, prothrombin time and partial thromboplastint time tests were performed and resulted normal for the species. After a 7-day therapy, the patient presented complete improvement of its nervous signs and was discharged in normal condition. The use of pralidoxime as activator of acetylcholinesterase is an option in the treatment of severe intoxication with methomyl in canine species that exhibit sensitivity to carbamates.

Keywords : acetylcholine; acetylcholinesterase; canine; carbamates; insecticide.

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