Revista Colombiana de Anestesiología
versão impressa ISSN 0120-3347
Nitric oxide and endothelium-derived relaxing factor were considered a single entity, modulating vascular tone through the stimulated formation of cyclic guanosine 3',5'-monophosphate. Nitric oxide (NO), produced during the conversion of L-arginine to L-citrulline by NO synthase (NOS) isoforms, is a gaseous that mediates various functions, including smooth muscle relaxation, neurotransmission, immune cell cytotoxicity, effects of anesthetic agents and nociceptive pathways. This review will consider the biologic actions of nitric oxide.
Palavras-chave : Nitric oxide; nitric oxide synthase; peroxynitrite.