Abstract

TAFUR B, Luis Alberto; GOMEZ M, Juan Manuel  and  PARRA, Luis Eduardo. Validación de nomogramas de remifentanil y propofol para la administración de anestesia total endovenosa. Rev. colomb. anestesiol. [online]. 2009, vol.37, n.1, pp.21-28. ISSN 0120-3347.

Objective: To stablish the concordance of the Plasma Concentration obtained using nomograms for Remifentanil and Propofol vs. Computerized systems. Methods: Using the pharmacokinetic models of Marsh and Minto, we designed nomograms for remifentanil and porpofol respectively. We conducted a cross sectional analytic study as follows: we obtained Sixty-six samples from eleven patients who underwent procedures under total intravenous anesthesia (TIVA). Using the Rugloop software we calculated the plasma concentration from the samples. A blind observer also cal culated the plasma concentrations using the data from the infusion rate, the nomograms and the height and weight of each patient. Later the concordance between the two methods was evaluated. Statistical Methods: Linear regression ´ correlation analysis. We used analysis of variance in order to test the goodness of adjustment of the regression model. Level of statistical significance α = 0.01. Results. Pearson´s correlation coefficient between the computerized systems and nomograms is 0.96 [CI 95% (0.87-1)] y 0.87 [CI 95% (0.75-1)] for remifentanil and propofol respectively (p value < 0.001). Conclusions. There´s a significantly high correlation between the nomograms and the computerized systems. This nomograms are a cheaper, easy and accurate tools for predict remifentanil and propofol plasma concentration.

Keywords : Nomograms; remifentanyl; propofol; Total Intravenous Anesthesia.

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