Abstract

ANDERSON, Brian J. Pharmacology of paediatric total intravenous anaesthesia. Rev. colomb. anestesiol. [online]. 2013, vol.41, n.3, pp.205-214. ISSN 0120-3347.  https://doi.org/10.1016/j.rca.2013.05.008.

Adult parameter estimates for pharmacokinetic models over-predict plasma concentrations in children. Parameter sets that describe 3-compartment pharmacokinetic models for propofol have been published and some are now incorporated into commercially available paediatric infusion pumps. Pharmacokinetics in children is influenced by size and age. Other covariates remain poorly understood. There are no integrated pharmacokinetic-pharmacodynamic analyses available. However, methodology exists that enables us to link pharmacokinetic parameter sets with pharmacodynamic data in order to calculate a rate constant linking serum and effect site concentrations. Literature concerningpaediatric total intravenous anaesthesia was reviewed to appraise these parameter sets ('models') and to outline the pharmacology behind them, their limitations and pitfalls.

Keywords : Anesthesia; Pharmacokinetics; Pediatrics; Pharmacology; Propofol.

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