Resumo

DUENAS, Zulma. Ketamine improves survival in severe burn injury in rats via the expression of heat shock protein 70, far or close to the clinical perspective?. Rev. colomb. anestesiol. [online]. 2013, vol.41, n.4, pp.283-286. ISSN 0120-3347.  https://doi.org/10.1016/j.rca.2013.09.007.

The purpose ofthis reflectionorcommentary is notto demerit the efforts of the researchers, but rather to highlight some aspects that should be taken into account in the future for implementing experimental designs that may potentially contribute to strengthen the links between basic biomedical and clinical research, referring to the research article entitled Ketamine improves survival in severe burn injury in rats via the Expression of Heat Shock Protein 70. This is a purely constructive reflection aimed at encouraging those who are one way or other involved in research, to develop a more comprehensive analysis and a proposal for an experimental design that enables the extrapolation of the results from animal models to a clinical application, with a limited number of subjects but preserving the validity of the trial, in addition to making the best possible use of the experimental subjects and of there lationship between basic and clinical research. In fact, the ethical guidelines issued by the Councilfor International Organizations of Medical Sciences, in its chapteron animal experiments emphasize that the validity of a trial allows for using the minimum number of animals in an experiment. The article that makes reference to this matter was published by Zhang Meng-yuan et al., and concludes that Ketamine therapy improves the survival of patients with severe burn injuries via the expression of heat shock proteins in the heart and the brain.

Palavras-chave : Ketamine; Burns; Heat-Shock Proteins; Analgesia; Survivorship.

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