Abstract

TAFUR-BETANCOURT, Luis Alberto et al. From pharmacokinetics to pharmacodynamics -Are we ready for 3D software?. Rev. colomb. anestesiol. [online]. 2017, vol.45, n.4, pp.335-339. ISSN 0120-3347.

The relationship between the dose and plasma concentration of a drug is determined by pharmacokinetics. However, difficulties arise when more than one drug is administered simultaneously. There is currently a gap in the teaching model when trying to convey the significance of pharmacodynamic interactions. In this article the authors reflect on the importance of developing a software that simplifies the pharmacokinetic concepts of two drugs, turning them into one single variable in space as a function of time. Together with depth of anesthesia monitoring and the pain control variables, this model will bring pharmacokinetics and pharmacodynamics together and provide a teaching tool for improved understanding of these concepts.

Keywords : Anesthesia; intravenous; Balanced anesthesia; Pharmacology; Pharmacokinetics; Software.

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