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## Biomédica

*versão impressa* ISSN 0120-4157

*versão On-line* ISSN 2590-7379

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CARMONA-FONSECA, Jaime. **Correlation and interconversion between erythrocyte cholinesterase values obtained by the Michel and the EQM® techniques **.* Biomédica* [online]. 2006, vol.26, n.4, pp.546-555.
ISSN 0120-4157.

**Introduction. **Several techniques are available to measure red cell cholinesterase; therefore, evaluations with several methods provide a measure of concordance. **Objective.** An equation was formulated to transform native data of reference values to reference units of cholinesterase activity as measured by Michel and EQM® tests. **Materials and methods.** The experimental design was descriptive, transversal and prospective. The group sampled was a representative adult working population, aged 18-75, without previous exposure to cholinesterase inhibitors pesticides. The individuals were affiliated to the Social Security System and resided in Valle de Aburrá and Cercano Oriente Antioqueño (Antioquia Province, northwestern Colombia). **Results.** Of 827 individuals, quantitative erythrocytes (Michel y EQM®) tests exhibited "r" coefficients between 0.67 and R2 coefficient of 44%.,This indicated that one test explained the results in other test in 44% of the cases. The corelation was higher in Aburrá than in Oriente. The linear model for the 827 individuals was as follows: EQM U/g oxy-hemoglobin = 9.575 U/g oxy-hemoglobin + 29.791 (Michel delta pH/hour). Michel delta pH/hr = 0.3312 delta pH/hour + 0.0149 (EQM U/g oxy-hemoglobin), where EQM® was expressed in U/g oxy-hemoglobin and Michel pH change/hr. Inter-sections (coefficient a) and inclines (coefficient b) were significant in this model. In the adjusted equations, after exclusion of 12 extreme data (1.5% of 827), the r coefficient increased from 0.67 to 0.72 The adjusted equations were as follows: EQM U/g oxy-hemoglobin = 8.1884 U/g oxy-hemoglobin + 31.3920 (Michel delta pH/hour); Michel delta pH/hr = 0.2925 delta pH/hr + 0.0161 (EQM U/g oxy-hemoglobin). **Conclusion.** This system of linear equations permitted the transformation of Michel (delta PH/hr) units to EQM (U/g oxy-hemoglobin) units and vice versa. This will facilitate data comparisons by clinicians and epidemiologists who are using these methods of cholinesterase measurement.

**Palavras-chave
:
**acetylcholine; acetylcholinesterase; pesticides.