SciELO - Scientific Electronic Library Online

 
vol.29 número3Caracterización preliminar de los sitios de cría de Aedes (Stegomyia) albopictus (Skuse, 1894) (Diptera: Culicidae) en el municipio de Leticia, Amazonas, ColombiaSupervivencia de pacientes con cáncer de cuello uterino tratadas en el Instituto Nacional de Cancerología índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


Biomédica

versión impresa ISSN 0120-4157

Resumen

PAEZ, Andrés et al. Outbreak of urban rabies transmitted by dogs in Santa Marta, northern Colombia.. Biomédica [online]. 2009, vol.29, n.3, pp.424-436. ISSN 0120-4157.

Introduction. An urban rabies outbreak occurred in the District of Santa Marta between April 2006 and January 2008, which resulted in the deaths of 4 humans and 28 dogs. Objectives. Three objectives were entertained-first, the diagnostic laboratory techniques were described as well as the rabies control actions taken; second, the impact of anti-rabies dog vaccination was assessed in terms of neutralizing antibody seroconversion; and third, the epidemiological significance and public health implications of the outbreak were examined. Materials and methods. Rabies diagnosis was achieved by direct immunofluorescence, inoculation of mice and immunohistochemistry. Typing of the virus was achieved by indirect immunofluorescence. Control activities included a dog population census, vaccination and treatments for persons exposed to rabies, mass vaccination of dogs and cats, and initiation of a community education program. Seroconversion was investigated by capture ELISA. Results. Antigenic variant 1 was detected in all cases. Of vaccinated dogs, 77% were seropositive, and 47% were seroprotected against rabies. No differences were found in the humoral response between dog gender; however significant differences in dog seroprotection were discovered between localized comunities in Santa Marta. Conclusions. The 2006-2008 urban rabies outbreak was the largest reported in a city in Colombia. It was caused by rabid dogs, and demonstrated that these animals are still a threat for human health despite the existence of efficient rabies vaccines. The control of the outbreak was achieved 20 months after the first rabies case in dogs, and 14 months after the initiation of the first mass vaccination of animals. The necessity of implementation and maintenance of rabies control strategies is underlined for minimizing human risk.

Palabras clave : rabies; rabies virus; Lyssavirus; zoonoses; epidemiologic surveillance; Colombia.

        · resumen en Español     · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons